Article
Peroxisome proliferator-activated receptor γ ligands retard cultured vascular smooth muscle cells calcification induced by high glucose.
Cell biochemistry and biophysics - 1 Jul 2013
Zhou Ye-Bo, Zhang Jing, Peng Ding-Qiong, Chang Jin-Rui, Cai Yan, Yu Yan-Rong, Jia Mo-Zhi, Wu Wei, Guan You-Fei, Tang Chao-Shu, Qi Yong-Fen
Abstract excerpt
Peroxisome proliferator-activated receptor γ (PPARγ) and its ligands have profound effects on glucose homeostasis, cardiovascular diseases, and bone metabolism. To explore the pathophysiological roles of PPARγ in diabetes with concomitant vascular calcification, we investigated changes in PPARγ expression and the effect of the PPARγ ligands troglitazone and rosiglitazone on vascular smooth muscle cell (VSMC)...
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