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Oncogenes, Trousseau Syndrome, and Cancer-Related Changes in the Coagulome of Mice and Humans

15 Nov 2006

Abstract excerpt

Cancer is often associated with venous thrombosis, a phenomenon that was first described by Trousseau in 1865 (Trousseau syndrome). Recent studies have begun to explain how oncogenic events may deregulate the hemostatic system. For instance, activated oncogenes (K-ras, EGFR, PML-RARalpha, and MET) or inactivated tumor suppressors (e.g., 53 or PTEN) may increase the risk of thrombosis by inducing the expression of...

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PMID: 17108099
DOI: 10.1158/0008-5472.can-06-2350

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