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Article

JMJD1C Ensures Mouse Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression.

Stem cell reports - 12 Sept 2017

Xiao Feng, Liao Bing, Hu Jing, Li Shuang, Zhao Haixin, Sun Ming, Gu Junjie, Jin Ying

Abstract excerpt

The roles of histone demethylases (HDMs) for the establishment and maintenance of pluripotency are incompletely characterized. Here, we show that JmjC-domain-containing protein 1c (JMJD1C), an H3K9 demethylase, is required for mouse embryonic stem cell (ESC) self-renewal. Depletion of Jmjd1c leads to the activation of ERK/MAPK signaling and epithelial-to-mesenchymal transition (EMT) to induce differentiation of...

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Identifiers

PMID: 28826851
DOI: 10.1016/j.stemcr.2017.07.013
PMCID: PMC5599225

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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