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Article

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

17 Jul 2010

Abstract excerpt

SIRT1 is increasingly recognized as a critical regulator of stress responses, replicative senescence, inflammation, metabolism, and aging. SIRT1 expression is regulated transcriptionally and post-transcriptionally, and its enzymatic activity is controlled by NAD+ levels and interacting proteins. We found that SIRT1 protein levels were much higher in mouse embryonic stem cells (mESCs) than in differentiated...

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PMID: 20634564
DOI: 10.18632/aging.100176

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