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Article

Systems biology derived source-sink mechanism of BMP gradient formation.

eLife - 9 Aug 2017

Zinski Joseph, Bu Ye, Wang Xu, Dou Wei, Umulis David, Mullins Mary C

Abstract excerpt

A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to generate peak signaling levels. To delineate the mechanism in zebrafish, we precisely quantified the BMP activity gradient in...

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Identifiers

PMID: 28826472
DOI: 10.7554/eLife.22199
PMCID: PMC5590806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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