Article
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
Nature - 19 Sept 2002
Eldar Avigdor, Dorfman Ruslan, Weiss Daniel, Ashe Hilary, Shilo Ben-Zion, Barkai Naama
Abstract excerpt
Developmental patterning relies on morphogen gradients, which generally involve feedback loops to buffer against perturbations caused by fluctuations in gene dosage and expression. Although many gene components involved in such feedback loops have been identified, how they work together to generate a robust pattern remains unclear. Here we study the network of extracellular proteins that patterns the dorsal...
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