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Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins.

Developmental cell - 16 Feb 2010

Umulis David M, Shimmi Osamu, O'Connor Michael B, Othmer Hans G

Abstract excerpt

Advances in image acquisition and informatics technology have led to organism-scale spatiotemporal atlases of gene expression and protein distributions. To maximize the utility of this information for the study of developmental processes, a new generation of mathematical models is needed for discovery and hypothesis testing. Here, we develop a data-driven, geometrically accurate model of early Drosophila...

Topics

Animals
Body Patterning
Bone Morphogenetic Proteins
Collagen Type IV
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Feedback, Physiological
Gene Expression Regulation, Developmental
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Imaging, Three-Dimensional

Models, Biological

Mutation

Signal Transduction

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20159596
DOI: 10.1016/j.devcel.2010.01.006
PMCID: PMC2848394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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