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Article

GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson's Disease.

International journal of molecular sciences - 23 Feb 2021

Cerri Silvia, Ghezzi Cristina, Ongari Gerardo, Croce Stefania, Avenali Micol, Zangaglia Roberta, Di Monte Donato A, Valente Enza Maria, Blandini Fabio

Abstract excerpt

Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson's disease (PD). The molecular mechanisms underlying the increased PD risk and the variable phenotypes observed in carriers of different GBA mutations are not yet fully elucidated. Extracellular vesicles (EVs) have gained increasing importance in...

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Identifiers

PMID: 33672321
DOI: 10.3390/ijms22042215
PMCID: PMC7927041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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