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Article

Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000

Minowa O, Arai T, Hirano M, Monden Y, Nakai S, Fukuda M, Itoh M, Takano H, Hippou Y, Aburatani H, Masumura K, Nohmi T, Nishimura S, Noda T

Abstract excerpt

The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine or 7, 8-dihydro-8-oxoguanine (8-OH-G). Products of the human MMH/OGG1 gene are known to catalyze in vitro the reactions repairing this DNA lesion. To analyze the function of Mmh in vivo, we generated a mouse line carrying a mutant Mmh allele by targeted gene disruption. Mmh homozygous mutant mice were found to...

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Source

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Identifiers

PMID: 10725358
DOI: 10.1073/pnas.050404497
PMCID: PMC18180

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.PMID 10725358Read ↗

Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA.Semantic proximity Read ↗

Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA.Semantic proximity Read ↗

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.Semantic proximity Read ↗

Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice.Semantic proximity Read ↗

High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress.Semantic proximity Read ↗

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.Semantic proximity Read ↗

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.Semantic proximity Read ↗

Functional cooperation of Ogg1 and Mutyh in preventing G: C-->T: a transversions in mice.Semantic proximity Read ↗

Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA.Semantic proximity Read ↗

Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence.Semantic proximity Read ↗

The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death.Semantic proximity Read ↗

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis.Semantic proximity Read ↗

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