Article
UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma.
DNA repair - 1 Feb 2023
Sanford Samantha L, Opresko Patricia L
Abstract excerpt
Understanding how benign nevi can progress to invasive and metastatic Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, USAelanoma is critical for developing interventions and therapeutics for this most deadly form of skin cancer. UV-induced mutations in the telomerase TERT gene promoter occur in the majority of melanomas but fail to prevent telomere shortening...
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