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Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi

24 Sept 2015

Abstract excerpt

Telomeres are tandem repeats of the noncoding DNA structures at the end of human chromosomes that protect the coding DNA and the integrity of the genome (Blackburn, 1991). The ability to sustain telomere length confers unlimited proliferative capacity to cancer cells. In most cancers telomere length is maintained by the activity of the enzyme telomerase (Kim et al., 1994), whose catalytic subunit is encoded by...

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PMID: 26763461
DOI: 10.1038/jid.2015.374

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Related research

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Research trail→

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Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital NeviPMID 26763461Read ↗

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.Semantic proximity Read ↗

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Telomerase promoter mutations in cancer: an emerging molecular biomarker?Semantic proximity Read ↗

TERT promoter mutations in cancer development.Semantic proximity Read ↗

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma.Semantic proximity Read ↗

Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression.Semantic proximity Read ↗

TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic ApoptosisSemantic proximity Read ↗

TERT promoter mutations in familial and sporadic melanoma.Semantic proximity Read ↗

Highly recurrent TERT promoter mutations in human melanoma.Semantic proximity Read ↗

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