Article
TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Science (New York, N.Y.) - 11 Nov 2022
Chun-On Pattra, Hinchie Angela M, Beale Holly C, Gil Silva Agustin A, Rush Elizabeth, Sander Cindy, Connelly Carla J, Seynnaeve Brittani K N, Kirkwood John M, Vaske Olena M, Greider Carol W, Alder Jonathan K
Abstract excerpt
Overcoming replicative senescence is an essential step during oncogenesis, and the reactivation of TERT through promoter mutations is a common mechanism. TERT promoter mutations are acquired in about 75% of melanomas but are not sufficient to maintain telomeres, suggesting that additional mutations are required. We identified a cluster of variants in the promoter of ACD encoding the shelterin component TPP1. ACD...
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