Article
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.
The Journal of experimental medicine - 4 Jul 2011
Li Yuejuan, Jiang Dianhua, Liang Jiurong, Meltzer Eric B, Gray Alice, Miura Riu, Wogensen Lise, Yamaguchi Yu, Noble Paul W
Abstract excerpt
Tissue fibrosis is a major cause of morbidity, and idiopathic pulmonary fibrosis (IPF) is a terminal illness characterized by unremitting matrix deposition in the lung. The mechanisms that control progressive fibrosis are unknown. Myofibroblasts accumulate at sites of tissue remodeling and produce extracellular matrix components such as collagen and hyaluronan (HA) that ultimately compromise organ function. We...
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