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Article

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice.

PLoS genetics - 1 Aug 2017

Snouffer Ashley, Brown Desmond, Lee Hankyu, Walsh Jonathon, Lupu Floria, Norman Ryan, Lechtreck Karl, Ko Hyuk Wan, Eggenschwiler Jonathan

Abstract excerpt

The Hedgehog (Hh) signaling pathway plays a key role in cell fate specification, proliferation, and survival during mammalian development. Cells require a small organelle, the primary cilium, to respond properly to Hh signals and the key regulators of Hh signal transduction exhibit dynamic localization to this organelle when the pathway is activated. Here, we investigate the role of Cell Cycle Related kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28817564
DOI: 10.1371/journal.pgen.1006912
PMCID: PMC5574612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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