Article
MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.
Cell metabolism - 6 Oct 2015
Sancho Patricia, Burgos-Ramos Emma, Tavera Alejandra, Bou Kheir Tony, Jagust Petra, Schoenhals Matthieu, Barneda David, Sellers Katherine, Campos-Olivas Ramon, Graña Osvaldo, Viera Catarina R, Yuneva Mariia, Sainz Bruno, Heeschen Christopher
Abstract excerpt
The anti-diabetic drug metformin targets pancreatic cancer stem cells (CSCs), but not their differentiated progenies (non-CSCs), which may be related to distinct metabolic phenotypes. Here we conclusively demonstrate that while non-CSCs were highly glycolytic, CSCs were dependent on oxidative metabolism (OXPHOS) with very limited metabolic plasticity. Thus, mitochondrial inhibition, e.g., by metformin, translated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.