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Article

A kinase of many talents: non-neuronal functions of CDK5 in development and disease

1 Jan 2020

Abstract excerpt

The cyclin-dependent kinase 5 (CDK5) represents an unusual member of the family of cyclin-dependent kinases, which is activated upon binding to non-cyclin p35 and p39 proteins. The role of CDK5 in the nervous system has been very well established. In addition, there is growing evidence that CDK5 is also active in non-neuronal tissues, where it has been postulated to affect a variety of functions such as the...

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PMID: 31910742
DOI: 10.1098/rsob.190287

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