Article

Cyclin Dependent Kinase 5 (CDK5) Regulates the Circadian Clock

2019-08-07

Abstract excerpt

Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here we show that the cyclin-dependent kinase 5 (CDK5) regulates the mam...

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Literature Corpus work: b8e3f10c-c51d-5f74-82dd-ff95463466cd
DOI: 10.1101/728733

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