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Article

Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling.

PloS one - 1 Jan 2013

Jeong Jaehoon, Park Young-Un, Kim Dae-Kyum, Lee Saebom, Kwak Yongdo, Lee Seol-Ae, Lee Haeryun, Suh Yoo-Hun, Gho Yong Song, Hwang Daehee, Park Sang Ki

Abstract excerpt

The dopamine D2 receptor (DRD2) is a key receptor that mediates dopamine-associated brain functions such as mood, reward, and emotion. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit. In this study, we revealed that the serine 321 residue (S321) in the third intracellular loop of DRD2 (D2i3) is a novel regulatory site of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24391960
DOI: 10.1371/journal.pone.0084482
PMCID: PMC3877277

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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