Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.

Experimental neurology - 1 Nov 2015

Liu Jiao, Du Junxie, Yang Yanrui, Wang Yun

Abstract excerpt

Cyclin-dependent kinase 5 (Cdk5) is an important serine/threonine kinase that plays critical roles in many physiological processes. Recently, Cdk5 has been reported to phosphorylate TRPV1 at threonine 407 (Thr-407) in humans (Thr-406 in rats), which enhances the function of TRPV1 channel and promotes thermal hyperalgesia in the complete Freund's adjuvant (CFA)-induced inflammatory pain rats. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Cyclin-Dependent Kinase 5
Share to Ganglia, Spinal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperalgesia

Share to Kinesins

Share to Phosphotransferases

Share to Threonine

Share to TRPV Cation Channels

Source

Identifiers

PMID: 26376215
DOI: 10.1016/j.expneurol.2015.09.005

Genes

TRPV1
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia.PMID 26376215Read ↗

Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.Semantic proximity Read ↗

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.Semantic proximity Read ↗

A comprehensive analysis reveals the therapeutic value of TRPV1 in cancersSemantic proximity Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.Semantic proximity Read ↗

Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse modelsSemantic proximity Read ↗

Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.Semantic proximity Read ↗

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.Semantic proximity Read ↗

Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.Semantic proximity Read ↗

Cyclin Dependent Kinase 5 (CDK5) Regulates the Circadian ClockSemantic proximity Read ↗

80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).Semantic proximity Read ↗

Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca²⁺-activated non-selective cation channel TRPM4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.