Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.

Abstract excerpt

Activation of the innate immune receptor NLRP1B leads to the formation of an inflammasome, which induces autoproteolytic processing of pro-caspase-1, and ultimately to the release of inflammatory cytokines and to the execution of pyroptosis. One of the signals to which NLRP1B responds is metabolic stress that occurs in cells deprived of glucose or treated with metabolic inhibitors. NLRP1B might therefore sense...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis Regulatory Proteins
• Share to Bacterial Toxins