Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against<i>Salmonella</i>

Abstract excerpt

Intracellular pathogens and endogenous danger signals in the cytosol engage NOD-like receptors (NLRs), which assemble inflammasome complexes to activate caspase-1 and promote the release of proinflammatory cytokines IL-1beta and IL-18. However, the NLRs that respond to microbial pathogens in vivo are poorly defined. We show that the NLRs NLRP3 and NLRC4 both activate caspase-1 in response to Salmonella...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Heme Oxygenase-1 and Carbon Monoxide
• Share to Inflammasome and immune disorders
• Share to Kawasaki Disease and Coronary Complications