Article
Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018
Mitchell Gabriel, Cheng Mandy I, Chen Chen, Nguyen Brittney N, Whiteley Aaron T, Kianian Sara, Cox Jeffery S, Green Douglas R, McDonald Kent L, Portnoy Daniel A
Abstract excerpt
Xenophagy is a selective macroautophagic process that protects the host cytosol by entrapping and delivering microbes to a degradative compartment. Both noncanonical autophagic pathways and xenophagy are activated by microbes during infection, but the relative importance and function of these distinct processes are not clear. In this study, we used bacterial and host mutants to dissect the contribution of...
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