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Stabilized coronavirus spike stem elicits a broadly protective antibody

19 Oct 2021

Abstract excerpt

Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineering to remove the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein and develop stabilized stem (SS) antigens. Vaccination with MERS SS...

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PMID: 34710354
DOI: 10.1016/j.celrep.2021.109929

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