Article
Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2017
Bertocci Barbara, Lecoeuche Damiana, Sterlin Delphine, Kühn Julius, Gaillard Baptiste, De Smet Annie, Lembo Frederique, Bole-Feysot Christine, Cagnard Nicolas, Fadeev Tatiana, Dahan Auriel, Weill Jean-Claude, Reynaud Claude-Agnès
Abstract excerpt
Klhl6 belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. Several of these proteins function as adaptors of the Cullin3 E3 ubiquitin ligase complex. In this article, we report that Klhl6 deficiency induces, as previously described, a 2-fold reduction in mature B cells. However, we find that this deficit is centered on the inability of...
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