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Article

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

11 May 2016

Abstract excerpt

The BCL6 proto-oncogene encodes a transcriptional repressor that is required for the germinal center (GC) reaction and is implicated in lymphomagenesis. BCL6 protein stability is regulated by F-box protein 11 (FBXO11)-mediated ubiquitination and degradation, which is impaired in ∼6% of diffuse large B-cell lymphomas that carry inactivating genetic alterations targeting the FBXO11 gene. In order to investigate the...

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PMID: 27166359
DOI: 10.1182/blood-2015-11-684357

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