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Article

Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene

14 Aug 2017

Abstract excerpt

Abstract Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display unique aggressive behavior, invading the articular cartilage and promoting inflammation. Using an integrative analysis of RA risk alleles, the transcriptome and methylome in RA FLS, we recently identified the limb bud and heart development (LBH) gene as a key dysregulated gene in RA and other autoimmune diseases. Although some evidence...

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PMID: 28807995
DOI: 10.4049/jimmunol.1700719

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