Joint-specific regulation of homeobox D10 expression in rheumatoid arthritis fibroblast-like synoviocytes

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic immune-mediated disease characterized by joint inflammation and destruction. The disease typically affects small joints in the hands and feet, later progressing to involve larger joints such as the knees, shoulders, and hips. While the reasons for these joint-specific differences are unclear, distinct epigenetic patterns associated with joint location have been reported. In...

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