Article
Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Development (Cambridge, England) - 15 Sept 2017
Carreno Gabriela, Apps John R, Lodge Emily J, Panousopoulos Leonidas, Haston Scott, Gonzalez-Meljem Jose Mario, Hahn Heidi, Andoniadou Cynthia L, Martinez-Barbera Juan Pedro
Abstract excerpt
Sonic hedgehog (SHH) is an essential morphogenetic signal that dictates cell fate decisions in several developing organs in mammals. In vitro data suggest that SHH is required to specify LHX3+/LHX4+ Rathke's pouch (RP) progenitor identity. However, in vivo studies have failed to reveal such a function, supporting instead a crucial role for SHH in promoting proliferation of these RP progenitors and for...
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