Article
Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development.
Development (Cambridge, England) - 1 Jul 2002
Mathieu Juliette, Barth Anukampa, Rosa Frederic M, Wilson Stephen W, Peyriéras Nadine
Abstract excerpt
Despite its evolutionary conservation and functional importance, little is known of the signaling pathways that underlie development of the hypothalamus. Although mutations affecting Nodal and Hedgehog signaling disrupt hypothalamic development, the time and site of action and the exact roles of these pathways remain very poorly understood. Unexpectedly, we show here that cell-autonomous reception of Nodal...
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