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Article

Structural basis of human PR/SET domain 9 (PRDM9) allele C-specific recognition of its cognate DNA sequence.

The Journal of biological chemistry - 29 Sept 2017

Patel Anamika, Zhang Xing, Blumenthal Robert M, Cheng Xiaodong

Abstract excerpt

PRDM9 is the only mammalian gene that has been associated with speciation. The PR/SET domain 9 (PRDM9) protein is a major determinant of meiotic recombination hot spots and acts through sequence-specific DNA binding via its C2H2 zinc finger (ZF) tandem array, which is highly polymorphic within and between species. The most common human variant, PRDM9 allele A (PRDM9a), contains 13 fingers (ZF1-13). Allele C...

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Identifiers

PMID: 28801461
DOI: 10.1074/jbc.M117.805754
PMCID: PMC5625032

Genes

PRDM9
SET

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Structural basis of human PR/SET domain 9 (PRDM9) allele C-specific recognition of its cognate DNA sequence.PMID 28801461Read ↗

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