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Article

Primate evolution of the recombination regulator PRDM9.

Nature communications - 8 Jul 2014

Schwartz Jerrod J, Roach David J, Thomas James H, Shendure Jay

Abstract excerpt

The PRDM9 gene encodes a protein with a highly variable tandem-repeat zinc finger (ZF) DNA-binding domain that plays a key role in determining sequence-specific hotspots of meiotic recombination genome wide. Here we survey the diversity of the PRDM9 ZF domain by sequencing this region in 64 primates from 18 species, revealing 68 unique alleles across all groups. We report ubiquitous positive selection at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25001002
DOI: 10.1038/ncomms5370
PMCID: PMC4110516

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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