Article
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
Science (New York, N.Y.) - 10 Aug 2018
Young Matthew D, Mitchell Thomas J, Vieira Braga Felipe A, Tran Maxine G B, Stewart Benjamin J, Ferdinand John R, Collord Grace, Botting Rachel A, Popescu Dorin-Mirel, Loudon Kevin W, Vento-Tormo Roser, Stephenson Emily, Cagan Alex, Farndon Sarah J, Del Castillo Velasco-Herrera Martin, Guzzo Charlotte, Richoz Nathan, Mamanova Lira, Aho Tevita, Armitage James N, Riddick Antony C P, Mushtaq Imran, Farrell Stephen, Rampling Dyanne, Nicholson James, Filby Andrew, Burge Johanna, Lisgo Steven, Maxwell Patrick H, Lindsay Susan, Warren Anne Y, Stewart Grant D, Sebire Neil, Coleman Nicholas, Haniffa Muzlifah, Teichmann Sarah A, Clatworthy Menna, Behjati Sam
Abstract excerpt
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms...
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