Article
A novel kernel for correcting size bias in the logistic kernel machine test with an application to rheumatoid arthritis.
Human heredity - 1 Jan 2012
Freytag Saskia, Bickeböller Heike, Amos Christopher I, Kneib Thomas, Schlather Martin
Abstract excerpt
OBJECTIVES: The logistic kernel machine test (LKMT) is a testing procedure tailored towards high-dimensional genetic data. Its use in pathway analyses of case-control genome-wide association studies results from its computational efficiency and flexibility in incorporating additional information via the kernel. The kernel can be any positive definite function; unfortunately, its form strongly influences the...
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