Article
Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.
World journal of gastroenterology - 21 Jul 2017
Lin Zhenwu, Wang Zhong, Hegarty John P, Lin Tony R, Wang Yunhua, Deiling Sue, Wu Rongling, Thomas Neal J, Floros Joanna
Abstract excerpt
AIM: To study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease (IBD). METHODS: A total of 159 pediatric inflammatory IBD patients (Crohn's disease, n = 136; ulcerative colitis, n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms (SNPs) of the IL-10 gene and the...
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