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Article

STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.

Journal of pediatric gastroenterology and nutrition - 1 Jul 2012

Willson Tara A, Kuhn Benjamin R, Jurickova Ingrid, Gerad Shaina, Moon David, Bonkowski Erin, Carey Rebecca, Collins Margaret H, Xu Huan, Jegga Anil G, Guthery Stephen L, Denson Lee A

Abstract excerpt

OBJECTIVES: Genotypic variation in signal transducer and activator of transcription 3 (STAT3) increases risk for inflammatory bowel disease (IBD), and STAT3-dependent inflammatory networks are induced in the colon in these patients. We hypothesized that STAT3 "A" risk allele carriage would be associated with increased cellular STAT3 activation and colon leukocyte recruitment. METHODS: Colonic expression of genes...

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Source

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Identifiers

PMID: 22197944
DOI: 10.1097/MPG.0b013e318246be78
PMCID: PMC3996847

Genes

STAT3
CXCR2
SOCS3
CXCL1
CXCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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