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Article

Strong overexpression of CXCR3 axis components in childhood inflammatory bowel disease.

Inflammatory bowel diseases - 1 Nov 2010

Schroepf Sebastian, Kappler Roland, Brand Stephan, Prell Christine, Lohse Peter, Glas Jürgen, Hoster Eva, Helmbrecht Johanna, Ballauff Antje, Berger Michael, von Schweinitz Dietrich, Koletzko Sibylle, Lacher Martin

Abstract excerpt

BACKGROUND: Inflammatory bowel disease (IBD) is a polygenetic disorder. Our group previously showed that a variant within the CXCL9 gene is associated with pediatric Crohn's disease. As CXCL9, CXCL10, and CXCL11 are the 3 ligands to the receptor CXCR3, the aim of this study was to investigate the colonic transcriptional activity of the CXCR3 axis and to perform SNP genotyping of a CXCL11 polymorphism in a large...

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Source

Identifiers

PMID: 20848514
DOI: 10.1002/ibd.21312

Genes

CXCR3
CXCL11
CXCL9
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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