Article
Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.
Molecular and cellular biology - 1 Nov 2017
Kaye Emily G, Kurbidaeva Amina, Wolle Daniel, Aoki Tsutomu, Schedl Paul, Larschan Erica
Abstract excerpt
Chromatin entry sites (CES) are 100- to 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome to upregulate expression of X-linked genes in male flies. CES contain one or more ∼20-bp GA-rich sequences called MSL recognition elements (MREs) that are critical for dosage compensation. Recent studies indicate that CES also correspond to boundaries of X-chromosomal topologically...
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