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Article

The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites.

Genetics - 1 Nov 2004

Schweinsberg Susan, Hagstrom Kirsten, Gohl Daryl, Schedl Paul, Kumar Ram P, Mishra Rakesh, Karch Francois

Abstract excerpt

In the work reported here we have analyzed the role of the GAGA factor [encoded by the Trithorax-like (Trl) gene] in the enhancer-blocking activity of Frontabdominal-7 (Fab-7), a domain boundary element from the Drosophila melanogaster bithorax complex (BX-C). One of the three nuclease hypersensitive sites in the Fab-7 boundary, HS1, contains multiple consensus-binding sequences for the GAGA factor, a protein...

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Identifiers

PMID: 15579691
DOI: 10.1534/genetics.104.029561
PMCID: PMC1448804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites.PMID 15579691Read ↗

dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element.Semantic proximity Read ↗

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.Semantic proximity Read ↗

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.Semantic proximity Read ↗

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.Semantic proximity Read ↗

Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.Semantic proximity Read ↗

Modulation of chromatin boundary activities by nucleosome-remodeling activities in Drosophila melanogaster.Semantic proximity Read ↗

Identification of a class of chromatin boundary elements.Semantic proximity Read ↗

A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.Semantic proximity Read ↗

GAGA factor isoforms have distinct but overlapping functions in vivo.Semantic proximity Read ↗

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.Semantic proximity Read ↗

Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex.Semantic proximity Read ↗

The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Semantic proximity Read ↗

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