Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3

7 Aug 2017

Abstract excerpt

Signal transducer and activator of transcription 3(STAT3) is an emerging target for cancer therapy. In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes in osteosarcoma. TSN selectively inactivates phospho-STAT3 (Tyr-705); subsequent molecular docking and in vitro SPR analysis uncover TSN directly binds to the SH2 domain of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Medicinal Plant Pharmacodynamics Research
Share to Microbial Natural Products and Biosynthesis
Share to Phytochemical compounds biological activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28783167
DOI: 10.1038/onc.2017.270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3PMID 28783167Read ↗

Small Molecule Inhibitors of STAT3 for Cancer TherapySemantic proximity Read ↗

Novel activators and small-molecule inhibitors of STAT3 in cancerSemantic proximity Read ↗

Strategies and Approaches of Targeting STAT3 for Cancer TreatmentSemantic proximity Read ↗

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancersSemantic proximity Read ↗

Critical analysis of the potential for targeting STAT3 in human malignancySemantic proximity Read ↗

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)Semantic proximity Read ↗

Transcription Factor STAT3 as a Novel Molecular Target for Cancer PreventionSemantic proximity Read ↗

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathwaySemantic proximity Read ↗

Synthesis and Evaluation of Naphthalene Derivatives as Potent STAT3 inhibitors and Agents Against Triple-Negative Breast Cancer Growth and MetastasisSemantic proximity Read ↗

Comprehensive Live-cell Imaging Analysis of Cryptotanshinone and Synergistic Drug-Screening Effects in Various Human and Canine Cancer Cell LinesSemantic proximity Read ↗

Signal transducer and activator of transcription 3 inhibitors: a patent reviewSemantic proximity Read ↗

Anti-tumor effects of cryptotanshinone (C19H20O3) in human osteosarcoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.