Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

21 Oct 2019

Abstract excerpt

Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting with metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are a potential cause of tumor metastasis, relapse, and chemotherapy resistance. Therefore, it is necessary to develop novel therapeutic drugs, which not only kill osteosarcoma cells but also target OSCs. This study aims to explore the anti-osteosarcoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cancer Mechanisms and Therapy
Share to Phytochemical compounds biological activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31631559
DOI: 10.1002/cam4.2612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathwayPMID 31631559Read ↗

EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.Semantic proximity Read ↗

TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cellsSemantic proximity Read ↗

Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanismsSemantic proximity Read ↗

Increased multi-drug resistance and reduced apoptosis in osteosarcoma side population cells are crucial factors for tumor recurrenceSemantic proximity Read ↗

Bufalin inhibits the differentiation and proliferation of human osteosarcoma cell line hMG63-derived cancer stem cellsSemantic proximity Read ↗

Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3Semantic proximity Read ↗

DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cellsSemantic proximity Read ↗

Theaflavin‐3,3′‐Digallate Plays a ROS‐Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and XenograftsSemantic proximity Read ↗

Inhibition of oleandrin on the proliferation and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathwaySemantic proximity Read ↗

Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.Semantic proximity Read ↗

Robinetin Modulates TGF-β/ERK Signaling and Tumor-Associated Phenotype in 3D Osteosarcoma Spheroids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.