Article
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Gastroenterology - 1 Nov 2017
Hegazy Ahmed N, West Nathaniel R, Stubbington Michael J T, Wendt Emily, Suijker Kim I M, Datsi Angeliki, This Sebastien, Danne Camille, Campion Suzanne, Duncan Sylvia H, Owens Benjamin M J, Uhlig Holm H, McMichael Andrew, Bergthaler Andreas, Teichmann Sarah A, Keshav Satish, Powrie Fiona
Abstract excerpt
BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of human CD4+ T cells to the intestinal microbiota. We measured the abundance of T cells in circulation and intestinal tissues that respond to intestinal microbes and determined their clonal...
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