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Article

Species-specific CD4+ T cells enable prediction of mucosal immune phenotypes from microbiota composition.

Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2023

Spindler Matthew P, Mogno Ilaria, Suri Prerna, Britton Graham J, Faith Jeremiah J

Abstract excerpt

How bacterial strains within a complex human microbiota collectively shape intestinal T cell homeostasis is not well understood. Methods that quickly identify effector strains or species that drive specific mucosal T cell phenotypes are needed to define general principles for how the microbiota modulates host immunity. We colonize germ-free mice with defined communities of cultured strains and profile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36917674
DOI: 10.1073/pnas.2215914120
PMCID: PMC10041165

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