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Article

Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood.

Molecular neurobiology - 1 Aug 2017

Li Yong, Ma Qingyi, Dasgupta Chiranjib, Halavi Shina, Hartman Richard E, Xiao Daliao, Zhang Lubo

Abstract excerpt

Accumulating evidence indicates a critical implication of DNA methylation in the brain development. We aim to determine whether the disruption of DNA methylation patterns in the developing brain adversely affects neurobehavioral phenotypes later in life in a sex-dependent manner. 5-Aza-2'-deoxycytidine (5-Aza), a DNA methylation inhibitor, was administered in newborn rats from postnatal day 1 to 3....

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Identifiers

PMID: 27311770
DOI: 10.1007/s12035-016-9957-4
PMCID: PMC5161729

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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