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Article

Overexpression of human-derived DNMT3A induced intergenerational inheritance of DNA methylation and gene expression variations in rat brain and testis.

Epigenetics - 1 Oct 2020

Li Zhenhua, Ma Yuanwu, Wang Guishuan, Wang Hanshu, Dai Yubing, Zhu Yu, Chen Shitao, Zheng Xiaoguo, Sun Fei

Abstract excerpt

In mammals, DNA methylation patterns are established by various types of DNA methyltransferases and can be stably passed on during cell division, thus creating a paradigm for epigenetic regulation that can mediate long-lasting changes in gene expression even when the initial triggering signal has disappeared. Although functional deficiency of DNMT3A, one of the methyltransferases, leads to abnormal DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32338148
DOI: 10.1080/15592294.2020.1749962
PMCID: PMC7518692

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