Article
SISTEM: simulation of tumor evolution, metastasis, and DNA-seq data under genotype-driven selection.
Bioinformatics (Oxford, England) - 1 Dec 2025
Weiner Samson, Bansal Mukul S
Abstract excerpt
SUMMARY: SISTEM is a software package and mathematical framework for simulating tumor evolution and cell migrations at single-cell resolution. Unlike existing frameworks which simulate cancer cell populations under the neutral coalescent or using simple birth-death models, SISTEM simulates tumor populations under somatic clonal selection using an agent-based framework. SISTEM can generate mutation profiles, read...
Read the complete abstract on PubMedTopics
- Software
- Humans
- Neoplasms
- Neoplasm Metastasis
- Sequence Analysis, DNA
- Genotype
- Mutation