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Article

Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.

Scientific reports - 3 Aug 2017

Kühn Frank J P, Mathis Winking, Cornelia Kühn, Hoffmann Daniel C, Lückhoff Andreas

Abstract excerpt

The archetypal TRPM2-like channel of the sea anemone Nematostella vectensis is gated by ADPR like its human orthologue but additionally exhibits properties of other vertebrate TRPM channels. Thus it can help towards an understanding of gating and regulation of the whole subfamily. To elucidate further the role of Ca2+ as a co-factor of ADPR, we exploited 2-aminoethyl diphenylborinate (2-APB), previously shown to...

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Identifiers

PMID: 28775320
DOI: 10.1038/s41598-017-07652-4
PMCID: PMC5543165

Genes

TRPM2

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