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Article

Modulation of TRPV4 gating by intra- and extracellular Ca2+.

Cell calcium - 1 Jan 2000

Watanabe Hiroyuki, Vriens Joris, Janssens Annelies, Wondergem Robert, Droogmans Guy, Nilius Bernd

Abstract excerpt

We have studied the modulation of gating properties of the Ca2+-permeable, cation channel TRPV4 transiently expressed in HEK293 cells. The phorbol ester 4alphaPDD transiently activated a current through TRPV4 in the presence of extracellular Ca2+. Increasing the concentration of extracellular Ca2+ ([Ca2+](e)) reduced the current amplitude and accelerated its decay. This decay was dramatically delayed in the...

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Source

Identifiers

PMID: 12765694
DOI: 10.1016/s0143-4160(03)00064-2

Genes

TRPV4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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