Article
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
The Journal of biological chemistry - 18 Jul 2008
Schindl Rainer, Bergsmann Judith, Frischauf Irene, Derler Isabella, Fahrner Marc, Muik Martin, Fritsch Reinhard, Groschner Klaus, Romanin Christoph
Abstract excerpt
Stim1 in the endoplasmic reticulum and the three Orai (also termed CRACM) channels in the plasma-membrane are main components of native Ca(2+) release-activated Ca(2+) channels. A pharmacological hallmark of these channels is their distinct sensitivity to 2-aminoethoxydiphenyl borate (2-APB). Here we report that Orai3 currents can be robustly stimulated by 75 microm 2-APB independent of Stim1, whereas 2-APB at...
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