Genome-Wide Association Study of Age-Related Macular Degeneration Reveals 2 New Loci Implying Shared Genetic Components with Central Serous Chorioretinopathy.

doi:10.1016/j.ophtha.2022.10.034

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Genome-Wide Association Study of Age-Related Macular Degeneration Reveals 2 New Loci Implying Shared Genetic Components with Central Serous Chorioretinopathy.

Ophthalmology - 1 Apr 2023

Akiyama Masato, Miyake Masahiro, Momozawa Yukihide, Arakawa Satoshi, Maruyama-Inoue Maiko, Endo Mikiko, Iwasaki Yusuke, Ishigaki Kazuyoshi, Matoba Nana, Okada Yukinori, Yasuda Miho, Oshima Yuji, Yoshida Shigeo, Nakao Shin-Ya, Morino Kazuya, Mori Yuki, Kido Ai, Kato Aki, Yasukawa Tsutomu, Obata Ryo, Nagai Yoshimi, Takahashi Kanji, Fujisawa Kimihiko, Miki Akiko, Nakamura Makoto, Honda Shigeru, Ushida Hiroaki, Yasuma Tetsuhiro, Nishiguchi Koji M, Mori Ryusaburo, Tanaka Koji, Wakatsuki Yu, Yamashiro Kenji, Kadonosono Kazuaki, Terao Chikashi, Ishibashi Tatsuro, Tsujikawa Akitaka, Sonoda Koh-Hei, Kubo Michiaki, Kamatani Yoichiro

Abstract excerpt

PURPOSE: To investigate the genetic architecture of age-related macular degeneration (AMD) in a Japanese population. DESIGN: Genome-wide association study (GWAS). PARTICIPANTS: Three thousand seven hundred seventy-two patients with AMD and 16 770 control participants from the Japanese population were enrolled in the association analyses. METHODS: We conducted a meta-analysis of 2 independent GWASs that included a...

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PMID: 36423732
DOI: 10.1016/j.ophtha.2022.10.034

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