Article
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
Nature genetics - 11 Sept 2011
Arakawa Satoshi, Takahashi Atsushi, Ashikawa Kyota, Hosono Naoya, Aoi Tomomi, Yasuda Miho, Oshima Yuji, Yoshida Shigeo, Enaida Hiroshi, Tsuchihashi Takashi, Mori Keisuke, Honda Shigeru, Negi Akira, Arakawa Akira, Kadonosono Kazuaki, Kiyohara Yutaka, Kamatani Naoyuki, Nakamura Yusuke, Ishibashi Tatsuro, Kubo Michiaki
Abstract excerpt
Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the world, is a complex disease caused by multiple environmental and genetic risk factors. To identify genetic factors that modify the risk of exudative AMD in the Japanese population, we conducted a genome-wide association study and a replication study using a total of 1,536 individuals with exudative AMD and 18,894 controls....
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